Opioid Receptor Subtypes and Ingestive Behavior
Shortly after the discovery of the opioid receptor in 1973, it became apparent that multiple opioid receptor subtypes (mu, delta, kappa and ORL-1) existed based on pharmacological, biochemical, anatomical and ultimately molecular evidence. Highly-specific and selective opioid receptor subtype agonists for the mu (e.g. DAMGO), delta-1 (e.g., DPDPE), delta-2 (e.g., deltorphin), kappa (e.g., U50488H) and ORL-1 (e.g., orphanin FQ-nociceptin) and antagonists for the mu (e.g., beta-funaltrexamine, CTOP), mu-1 (e.g., naloxonazine), delta (e.g., naltrindole) and kappa (e.g., nor-binaltorphamine) were developed and used by our laboratory and others to characterize which opioid receptor subtypes were involved in spontaneous intake and body weight gain in normal, developing, dietarily-obese and genetically-obese animals, in such regulatory challenges as food and water deprivation, glucoprivation and lipoprivation, in such stress-related issues as tail pinch feeding, and in such hedonic situations utilizing concentrations of sugars (e.g., sucrose), fats and starches (e.g., maltose dextrin). The orosensory characteristics of opioid function were studied using the sham-feeding paradigm minimizing post-ingestive factors.
Opioid Receptor Subtype and Feeding Publications of the Bodnar Laboratory:
Bodnar, RJ. Effects of opioid antagonists on feeding and appetite. In: Opioid Receptors and Antagonists: From Bench to Clinic, Contemporary Neuroscience Series, R Dean, E Bilsky and S Negus (Eds.) Humana Press: NJ, Chapter 20, pp. 379-398, 2008.
Bodnar, RJ. and AS Levine. Role of opioid peptides in regulating energy balance. In: Neurobiology and Obesity, J Harvey and DJ Withers (Eds.) Cambridge University Press, U.K., Chapter 8, pp. 232-265, 2008.
180. Cole, JL, A Ross and RJ Bodnar. Dietary history affects the potency of chronic opioid receptor subtype antagonist effects upon body weight in rats. Nutritional Neuroscience 1: 405-418, 1999.
Bodnar, RJ. Recent advances in the understanding of the effects of opioid agents on feeding and appetite. Exp. Opin. Invest. Drugs 7: 1-13, 1998.
168. Cole, JL, N Berman and RJ Bodnar. Differential sensitivity to body weight reductions following chronic central opioid receptor subtype antagonists in lean and obese Zucker rats. Peptides 18: 1201-1207, 1997.
Ruegg, H, W-Z Yu and RJ Bodnar. Opioid receptor subtype agonist-induced enhancements of sucrose intake are dependent upon sucrose concentration. Physiol. Behav. 62: 121-128, 1997.
Yu, W-Z and RJ Bodnar. Interactions between Angiotensin II and delta opioid receptor subtype agonists upon water intake in rats. Peptides 18: 241-245, 1997.
Yu, W-Z, H Ruegg and RJ Bodnar. Delta and kappa opioid receptor subtypes and ingestion: Antagonist and glucoprivic effects. Pharmacol. Biochem. Behav. 56: 353-361, 1997.
Leventhal, L and RJ Bodnar. Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats. Brain Res. 741: 300-308, 1996.
Leventhal, L, JL Cole and RJ Bodnar. Selective alterations in locomotor activity following central opioid receptor subtype antagonists in rats. Physiol. Behav. 60: 833-836, 1996.
Bodnar, RJ. Opioid receptor subtype antagonists and ingestion. In: Drug Receptor Subtypes and Ingestive Behavior, (Eds., SJ Cooper and PJ Clifton) Academic Press LTD: London, Chapter 6, 127-146, 1996.
Leventhal, L, TC Kirkham, JL Cole and RJ Bodnar. Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-feeding rats. Brain Res. 685: 205-210, 1995.
Cole, JL, L Leventhal, GW Pasternak, WD Bowen and RJ Bodnar. Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats. Brain Res. 678: 168-176, 1995.
Bodnar, RJ, MJ Glass and JE Koch. Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats. Brain Res. Bull. 36: 293-300, 1995.
Glass, MJ, B Hahn, A Joseph and RJ Bodnar. Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats. Brain Res. 657: 310-314, 1994.
Koch, JE and RJ Bodnar. Selective alterations in macronutrient intake of food-deprived or gluco-privic rats by centrally-administered opioid receptor subtype antagonists. Brain Res. 657: 191-201, 1994.
Schaefer, LA, JE Koch and RJ Bodnar. Naltrexone, dopamine receptor agonists and antagonists and food intake in rats: 2. 2-deoxy-D-glucose. Pharmacol. Biochem. Behav. 49: 205-211, 1994.
Hobbs, DJ, JE Koch and RJ Bodnar. Naltrexone, dopamine receptor agonists and antagonists and food intake in rats: 1. Food deprivation. Pharmacol. Biochem. Behav. 49: 197-204, 1994.
Islam, AK, T Dougherty, JE Koch and RJ Bodnar. Naltrexone, serotonin receptor subtype antagonists and carbohydrate intake in rats. Pharmacol. Biochem. Behav. 48: 193-201, 1994.
Ruegg, H, B Hahn, JE Koch and RJ Bodnar. Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats. Brain Res. 635: 203-210, 1994.
Islam, AK, IW Beczkowska and RJ Bodnar. Interactions among aging, gender and gonadectomy effects upon naloxone hypophagia in rats. Physiol. Behav. 54: 981-992, 1993.
Beczkowska, IW, JE Koch, ME Bostock, SF Leibowitz and RJ Bodnar. Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats. Brain Res. 618: 261-270, 1993.
Koch, JE and RJ Bodnar. Involvement of central mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats. Physiol. Behav. 53: 603-605, 1993.
Beczkowska, IW, WD Bowen and RJ Bodnar. Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats. Brain Res. 589: 291-301, 1992.
Koch, JE, GW Pasternak, D Arjune and RJ Bodnar. Naloxone benzoylhydrazone, a kappa3 opioid agonist, stimulates food intake in rats. Brain Res. 581: 311-314, 1992.
Koch, JE, IW Beczkowska and RJ Bodnar. Naltrexone, serotonin receptor subtype antagonists and glucoprivic intake: II. insulin. Pharmacol. Biochem. Behav. 42: 671-680, 1992.
Beczkowska, IW, JE Koch and RJ Bodnar. Naltrexone, serotonin receptor subtype antagonists and glucoprivic intake: I. 2-deoxy-D-glucose. Pharmacol. Biochem. Behav. 42: 661-669, 1992.
Arjune, D, WD Bowen and RJ Bodnar. Ingestive behavior following central [D-Ala2,Leu5,Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor. Pharmacol. Biochem. Behav. 39: 429-436, 1991.
Beczkowska, IW and RJ Bodnar. Mediation of insulin hyperphagia by specific central opiate receptor antagonists. Brain Res. 547: 315-318, 1991.
Beczkowska, IW and RJ Bodnar. Naloxone and serotonin receptor subtype antagonists: interactive effects upon deprivation-induced intake. Pharmacol. Biochem. Behav. 38: 605-610, 1991.
Arjune, D and RJ Bodnar. Suppression of nocturnal, palatable and glucoprivic intake in rats by the kappa opioid antagonist, nor-binaltorphamine. Brain Res. 534: 313-316, 1990.
Arjune, D, KM Standifer, GW Pasternak and RJ Bodnar. Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions. Brain Res. 535: 101-109, 1990.
Arjune, D and RJ Bodnar. Inhibition of deprivation-induced feeding by naloxone and cholecystokinin in rats: effects of central alloxan. Brain Res. Bull. 24: 375-379, 1990.
Islam, AK and RJ Bodnar. Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats. Brain Res. 508: 293-296, 1990.
Bodnar, RJ, GW Pasternak, PE Mann, D Paul, R Warren and DB Donner. Tumor necrosis factor (TNF) induces anorexia in the rat: evidence for a peripherally-mediated action. Cancer Res. 49: 6280-6284, 1989.
Mann, PE, GW Pasternak, EF Hahn, G Curreri, E Lubin and RJ Bodnar. Comparison of chronic naloxone and naloxonazine effects upon food intake and body weight maintainance in rats. Neuropharmacol. 27: 349-355, 1988.
Mann, PE, D Arjune, M-T Romero, GW Pasternak, EF Hahn and RJ Bodnar. Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine. Psychopharmacol. 94: 330-341, 1988.
Bodnar, RJ, PE Mann, M-T Romero and LS Truesdell. Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats. Life Sci. 38: 947-950, 1986.
Simone, DA, RJ Bodnar, EJ Goldman and GW Pasternak. Involvement of opioid receptor subtypes in rat feeding behavior. Life Sci. 36: 829-833, 1985.
Bodnar, RJ and PD Butler. Modulation of deprivation-induced food intake by D-phenylalanine. Int. J. Neurosci. 20: 295-301, 1983.